Bile: miRNA pattern and protein-based biomarkers may predict acute cellular rejection after liver transplantation.

Autor:	Schmuck, Rosa Bianca, Reutzel-Selke, Anja, Raschzok, Nathanael, Morgul, Haluk Mehmet, Struecker, Benjamin, Lippert, Steffen, de Carvalho Fischer, Cynthia, Schmelzle, Moritz, Boas-Knoop, Sabine, Bahra, Marcus, Pascher, Andreas, Pratschke, Johann, Sauer, Igor M.
Předmět:	LIVER transplantation MICRORNA BILE IMMUNOSUPPRESSIVE agents INDIVIDUALIZED medicine
Zdroj:	Biomarkers; Feb2017, Vol. 22 Issue 1, p19-27, 9p
Abstrakt:	Context: Bile rather than blood depicts the local inflammation in the liver and may improve prediction and diagnosis of acute cellular rejection (ACR) after liver transplantation (OLT). Methods: Secretome and miRNAs were analyzed during the first two weeks and on clinical suspicion of ACR in the bile of 45 OLT recipients. Results: Levels of CD44, CXCL9, miR-122, miR-133a, miR-148a and miR-194 were significantly higher in bile of patients who developed ACR within the first 6 months after OLT and during ACR. Conclusion: Analysis of secretome and miRNA in bile could improve our understanding of the local inflammatory process during rejection. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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