Alkaloids and Phenolic Compounds from Sida rhombifolia L. (Malvaceae) and Vasorelaxant Activity of Two Indoquinoline Alkaloids.

Autor: Chaves, Otemberg Souza, Teles, Yanna Carolina Ferreira, de Oliveira Monteiro, Matheus Morais, das Graças Mendes Junior, Leônidas, de Fátima Agra, Maria, de Andrade Braga, Valdir, Silva, Tânia Maria Sarmento, de Souza, Maria de Fátima Vanderlei
Zdroj: Molecules; Jan2017, Vol. 22 Issue 1, p94, 9p
Abstrakt: The follow-up of phytochemical and pharmacological studies of Sida rhombifolia L. (Malvaceae) aims to strengthen the chemosystematics and pharmacology of Sida genera and support the ethnopharmacological use of this species as hypotensive herb. The present work reports phytoconstituents isolated and identified from aerial parts of S. rhombifolia by using chromatographic and spectroscopic methods. The study led to the isolation of scopoletin (1), scoporone (2), ethoxy-ferulate (3), kaempferol (4), kaempferol-3-O-β-D-glycosyl-6″-α-D-rhamnose (5), quindolinone (6), 11-methoxy-quindoline (7), quindoline (8), and the cryptolepine salt (9). The alkaloids quindolinone (6) and cryptolepine salt (9) showed vasorelaxant activity in rodent isolated mesenteric arteries. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index