Early Motor Fluctuations in a Patient with Striatonigral Degeneration.

Autor:	Yoshii, Fumihito, Moriya, Yusuke, Ohnuki, Tomohide, Takahashi, Wakoh, Ryo, Masafuchi
Předmět:	DEGENERATION (Pathology) DOPA MAGNETIC resonance imaging MOVEMENT disorders RADIOACTIVITY DIAGNOSIS THERAPEUTICS
Zdroj:	Case Reports in Neurology; Sep-Dec2016, Vol. 8 Issue 3, p243-250, 8p
Abstrakt:	We report a 44-year-old female with striatonigral degeneration (SND) who showed wearingoff oscillations after 4 months of levodopa treatment. The patient presented with asymmetric left-side dominant rigidity, and levodopa was effective at first. However, she began to show wearing-off oscillations of motor symptoms, which gradually worsened thereafter. Fluidattenuated inversion recovery sequence magnetic resonance imaging (MRI) showed linear lateral putamen hyperintensities, and positron emission tomography (PET) studies using 18Ffluorodopa (FD) and 11C-N-methylspiperon (NMSP) showed a marked decrease of radioactivity in the right putamen, especially in the posterior putamen. The results of MRI and 2 PET studies with FD and NMSP were well consistent with the diagnosis of SND. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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