| Autor: |
بختی, سیده زهرا, قلیزاده, شکوفه, لطیفی نوید, سعید, زهری, صابر, فیضی, فریده, یزدانبد, عباس |
| Zdroj: |
Iranian Journal of Gastroenterology & Hepatology (GOVARESH); Autumn2016, Vol. 21 Issue 3, p176-184, 9p |
| Abstrakt: |
Background: Helicobacter pylori (H. pylori) is the main cause of gastroduodenal diseases, such as chronic atrophic gastritis, gastric ulcer (GU), and duodenal ulcer (DU). There is a close relationship between H. pylori-specific factors and different gastroduodenal diseases. The aim of the present study was to clarify the roles of the plasticity region genes (jhp0940, jhp0945, and jhp0947) and the known genes of cagPAI (cagA and cagE) in relation to GU and DU diseases. Materials and Methods: A total of 173 strains that were isolated from 114 patients with non-atrophic gastritis (NAG), 30 patients with DU, and 29 patients with GU were genotyped. Data were collected and analyzed using SPSS software version 19. Results: The cagE gene had the highest frequency (69.4%) and jhp0945 had the least frequency (11.0%) among the genes. When GU was considered as a dependant factor in simple logistic regression analysis, no genotype correlation was found with risk for GU in Iran (P>0.05). Statistical analysis showed that cagA+ and cagA+/ jhp0940+genotypes were significantly associated with an increased risk of DU but not GU. The Odds ratios (95% CI) were 3.143 (1.120-8.817), and 7.250 (1.493-38.199), respectively. Conclusion: Given the high frequency of cagE, this gene could be a suitable marker for the presence of cagPAI in Iranian strains. cagA+ and cagA+/ jhp0940+genotypes can be beneficial biomarkers for risk prediction of DU in Iran. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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