| Autor: |
Palmer, Kirsten R., Kaitu'u-Lino, Tu'uhevaha J., Cannon, Ping, Tuohey, Laura, De Silva, Manarangi S., Varas-Godoy, Manuel, Acuña, Stephanie, Galaz, José, Tong, Stephen, Illanes, Sebastián E. |
| Předmět: |
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| Zdroj: |
Journal of Maternal-Fetal & Neonatal Medicine; Mar2017, Vol. 30 Issue 6, p635-639, 5p |
| Abstrakt: |
Objective: sFLT-1 e15a is a recently described sFlt-1 variant that is placental and primate specific. As such, it may have potential as a biomarker. Using a newly developed ELISA, we measured maternal plasma sFLT-1 e15a levels in women with fetal growth restriction and pre-eclampsia.Method: We performed a nested case-control study where we measured total sFLT-1 and sFLT-1 e15a plasma protein concentrations. Samples, selected from a prospective cohort study, consisted of 87 healthy controls, 11 cases that developed term preeclampsia and 20 cases where there was fetal growth restriction. We also measured sFLT-1 and sFLT-1 e15a plasma concentrations in a separate cohort: 15 cases of preterm preeclampsia and 24 healthy controls.Results: The prospective case-control cohort demonstrated significantly increased sFLT-1 e15a among cases with term fetal growth restriction (p < 0.05). We also observed that total sFLT-1 (this ELISA indiscriminately detects all variants) was significantly increased in term preeclampsia (p < 0.0001), but not fetal growth restriction. The separate cohort of early-onset preeclamptics showed significantly increased sFLT-1 e15a levels (p < 0.0001).Conclusion: Plasma sFLT-1 e15a is significantly increased in early-onset preeclampsia and term fetal growth restriction. Further assessment of the benefit for sFLT-1 e15a testing in prediction or diagnosis of these disease states is warranted. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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