| Autor: |
R., Larhbali, S., Ghomari-Bezzar, S., Didi, M., Lasgaa, N., Mekedder, S., Boubou, H., Aliane, Charif |
| Předmět: |
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| Zdroj: |
Pan Arab Journal of Oncology; Jun2016, Vol. 9 Issue 2, p34-34, 1p |
| Abstrakt: |
Introduction: Nasopharyngeal carcinoma is one of the most common epithelial tumors of children and young adults in areas with intermediate risk. The Epstein-Barr virus (EBV) is the most important etiological factor. Its role in its pathogenesis has been confirmed by many studies. Undifferentiated carcinoma of nasopharyngeal type (UCNT) represents the most frequent histological type. The aim of our study was to evaluate clinical features, treatment modalities and prognosis outcomes in young patients treated for nasopharyngeal carcinoma. Methods: We retrospectively reviewed patients 30 years of age or younger who were treated for nasopharyngeal carcinoma (NPC) between 2013 and 2015 at the Oncology Department of Tidjani Damerdji University Hospital of Tlemcen. Results: Eleven patients were identified; this population represented 16,9% of the 65 cases of NPC collected at our department during the same period. Mean age was 24 years (14- 30). There were 3 females and 8 males. A family history of NPC was found in 2 cases. The average consultation was 6, 4 months. On the clinical level, it was a cervical lymphadenopathy with or without rhinological, otological or neurological signs. Rhinological signs were present in 9 cases, mainly nasal obstruction (13,4%) with epistaxis (34,3%). Otological signs were in 43%. Hearing loss was the most common sign. The cranial nerves lesions were in 27,2% of cases. The initial assessment had included a nasal a nasal fibroscopy with biopsy. CT-scan and/or MRI of nasopharynx and neck, chest radiography, abdominal ultrasound and bone scan. The pathological type was undifferentiated carcinoma in 10 of cases and squamous cell carcinoma in one case. Three patients had stage II disease, two patients had stage III disease, six had stage IVa- IVb. Treatment consisted of induction cisplatin based chemotherapy followed by radiotherapy or chemoradiotherapy for stages III, IVa and VIb disease. At a median follow up of 9 months, there were one local recurrence and 10 patients are free of disease. Currently, all patients were alive. Conclusion: Nasopharyngeal carcinoma in children and young adults is often diagnosed when locally advanced. Multimodal therapy provides better local control rates with acceptable early toxicity comparable to that of the adult but more late toxicity. New radiation techniques and new chemotherapy drugs could improve these results. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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