Amphiphilic Imbalance and Stabilization of Block Copolymer Micelles on-Demand through Combinational Photo-Cleavage and Photo-Crosslinking.

Autor:	Zhang, Xuan, Wang, Youpeng, Li, Guo, Liu, Zhaotie, Liu, Zhongwen, Jiang, Jinqiang
Předmět:	CROSSLINKING (Polymerization) COPOLYMERS ALTERNATING copolymers MICELLES synthesis EMISSION spectroscopy TRANSMISSION electron microscopy
Zdroj:	Macromolecular Rapid Communications; Jan2017, Vol. 38 Issue 1, pn/a-N.PAG, 7p
Abstrakt:	An amphiphilic block copolymer of poly(ethylene oxide)- b-poly(( N-methacryloxy phthalimide)- co-(7-(4-vinyl-benzyloxyl)-4-methylcoumarin)) (PEO45- b-P(MAPI36- co-VBC4)) is designed to improve the micellar stability during the photo-triggered release of hydrophobic cargoes. Analysis of absorption and emission spectra, solution transmittance, dynamic light scattering, and transmission electron microscopy supports that polymer micelles of PEO45- b-P(MAPI36- co-VBC4) upon the combinational irradiation of 365 and 254 nm light can be solubilized through the photolysis of phthalimide esters and simultaneously crosslinked via the partially reversible photo-dimerization of coumarins. The photo-triggered release experiment shows that the leakage of doxorubicin molecules from crosslinked micelles can be predictably regulated by controlling the irradiation time of 365 and 254 nm light. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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