Heat-shock protein HSP70 reduces the secretion of TNFα by neuroblastoma cells and human monocytes induced with beta-amyloid peptides.

Autor: Yurinskaya, M., Mit'kevich, V., Evgen'ev, M., Makarov, A., Vinokurov, M.
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Zdroj: Molecular Biology; Nov2016, Vol. 50 Issue 6, p930-932, 3p
Abstrakt: The progress of neurodegeneration in Alzheimer's disease is closely associated with inflammatory processes in the brain tissues induced by beta-amyloid peptides (Aβ). In this paper, we showed that Aβ(1-42) and isoAβ(1-42) in human neuroblastoma cells SK-N-SH and promonocyte THP-1 activated the production of tumor necrosis factor (TNFα). Notably, isoAβ(1-42) had the strongest effect on the increase in the level of TNFα. The addition of recombinant heat-shock protein HSP70 reduces TNFα production induced by Aβ, which leads to a decrease in neuronal cell damage at the organism level. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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