The Human Chromosomal Fragile Sites More Often Involved in Constitutional Deletions and Duplications - a Genetic and Statistical Assessment.

Autor:	Gomes, Dora Prata, Sequeira, Inês J., Figueiredo, Carlos, Rueff, José, Brás, Aldina
Předmět:	CHROMOSOME fragments RECOMBINATION hotspots DESCRIPTIVE statistics HUMAN genome REGRESSION analysis
Zdroj:	AIP Conference Proceedings; 2016, Vol. 1790 Issue 1, p1-4, 4p, 4 Graphs
Abstrakt:	Human chromosomal fragile sites (CFSs) are heritable loci or regions of the human chromosomes prone to exhibit gaps, breaks and rearrangements. Determining the frequency of deletions and duplications in CFSs may contribute to explain the occurrence of human disease due to those rearrangements. In this study we analyzed the frequency of deletions and duplications in each human CFS. Statistical methods, namely data display, descriptive statistics and linear regression analysis were applied to analyze this dataset. We found that FRA15C, FRA16A and FRAXB are the most frequently involved CFSs in deletions and duplications occurring in the human genome. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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