Effect of root-extracts of Ficus benghalensis (Banyan) in memory, anxiety, muscle coordination and seizure in animal models.

Autor:	Panday, Dipesh Raj, Rauniar, G. P.
Předmět:	DRUG therapy for convulsions MUSCLE physiology ANIMAL experimentation ANXIETY AZEPINES BIOLOGICAL models SEIZURES (Medicine) DIAZEPAM LEARNING MEMORY MICE MOTOR ability PENTOBARBITAL PROBABILITY theory PLANT roots STATISTICAL sampling SLEEP SPASMS STATISTICS PLANT extracts DATA analysis DATA analysis software DESCRIPTIVE statistics MANN Whitney U Test ONE-way analysis of variance
Zdroj:	BMC Complementary & Alternative Medicine; 11/3/2016, Vol. 16, p1-13, 13p, 5 Color Photographs, 1 Diagram, 8 Charts, 5 Graphs
Abstrakt:	Background: Ficus benghalensis L. (Banyan) is a commonly found tree in Eastern Nepal. Its different plant parts are used for various neurological ailments. This study was performed in mice to see its effects in various neuropharmacological parameters. Methods: Passive-avoidance (memory), Open-field (anxiety), Pentobarbital-induced Sleep potentiation (sleep), Rota- rod (muscle-co-ordination), Pentylenetetrazol-Induced and Maximal Electroshock Seizure Tests were performed. Sample size was calculated using G*Power 3.1.9.2. Aqueous root extracts (Soxhlet method) of Ficus benghalensis 100 mg/kg and 200 mg/kg with negative and positive controls were used. The experimental results were represented as Mean ± SD. P-value was set at <0.05. Oneway analysis of variance (ANOVA) or Mann-Whitney U test was appropriately used. Results: Passive-avoidance test showed 200 mg/kg group spent significantly less. Time (0.00s + 0.00s) in shock-zone than Normal Saline-group (9.67 s + 14.36 s, P = 0.000) or Diazepam-group (41.07 s + 88.24 s, P = 0.000). Open-field test showed 200 mg/kg group spent significantly longer Time (24.77 s + 12.23 s) in central-square than either Normal Saline group (15.08 s + 6.81 s, P = 0.000) or Diazepam-group (15.32 s + 5.12 s, P = 0.000). In Rota-rod test, 200 mg/kg group fell off the rod significantly (P = 0.000) earlier (33.01 s + 43.61 s) than both Normal Saline (>120 s) and Diazepam (62.07 s + 43.83 s) PTZ model showed that 100 mg/kg significantly (P = 0.004) delayed seizure-onset (184.40s + 36.36 s) compared to Normal Saline (101.79 s + 22.81 s), however, in MES model 200 mg/kg significantly (P = 0.000) prolonged tonic hind-limb extension (17.57 s + 2.15 s) compared to Normal Saline (13.55 s + 2. 75 s) or Phenytoin (00.00s + 00.00s). Conclusion: Aerial roots of Ficus benghalensis have memory-enhancing, anxiolytic, musclerelaxant, and seizure- modifying effect. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink