| Autor: |
Martin, Josiane Morais, Miranda, Rosiane Aparecida, Barella, Luiz Felipe, Palma-Rigo, Kesia, Alves, Vander Silva, Fabricio, Gabriel Sergio, Pavanello, Audrei, Franco, Claudinéia Conationi da Silva, Ribeiro, Tatiane Aparecida, Visentainer, Jesuí Vergílio, Banafé, Elton Guntendeorfer, Martin, Clayton Antunes, Mathias, Paulo Cezar de Freitas, de Oliveira, Júlio Cezar |
| Předmět: |
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| Zdroj: |
International Journal of Endocrinology; 12/5/2016, p1-10, 10p |
| Abstrakt: |
Essential polyunsaturated fatty acids (PUFAs) prevent cardiometabolic diseases. We aimed to study whether a diet supplemented with a mixture of n-6/n-3 PUFAs, during perinatal life, attenuates outcomes of long-term metabolic dysfunction in prediabetic and obese mice. Seventy-day-old virgin female mice were mated. From the conception day, dams were fed a diet supplemented with sunflower oil and flaxseed powder (containing an n-6/n-3 PUFAs ratio of 1.2 : 1.0) throughout pregnancy and lactation, while control dams received a commercial diet. Newborn mice were treated with monosodium L-glutamate (MSG, 4 mg g−1 body weight per day) for the first 5 days of age. A batch of weaned pups was sacrificed to quantify the brain and pancreas total lipids; another batch were fed a commercial diet until 90 days of age, where glucose homeostasis and glucose-induced insulin secretion (GIIS) as well as retroperitoneal fat and Lee index were assessed. MSG-treated mice developed obesity, glucose intolerance, insulin resistance, pancreatic islet dysfunction, and higher fat stores. Maternal flaxseed diet-supplementation decreased n-6/n-3 PUFAs ratio in the brain and pancreas and blocked glucose intolerance, insulin resistance, GIIS impairment, and obesity development. The n-6/n-3 essential PUFAs in a ratio of 1.2 : 1.0 supplemented in maternal diet during pregnancy and lactation prevent metabolic dysfunction in MSG-obesity model. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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