Blood-Based Oxidative Stress Markers and Cognitive Performance in Early Old Age: The HAPIEE Study.
| Autor: | Horvat, Pia, Kubinova, Ruzena, Pajak, andrzej, Tamosiunas, abdonas, Schöttker, Ben, Pikhart, Hynek, Peasey, anne, Kozela, Magdalena, Jansen, Eugene, Singh-Manoux, archana, Bobak, Martin |
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| Předmět: |
BIOMARKERS
CHI-squared test COGNITION disorders in old age CONFIDENCE intervals FREE radicals LONGITUDINAL method METROPOLITAN areas RESEARCH funding STATISTICAL sampling STATISTICAL hypothesis testing STUTTERING T-test (Statistics) OXIDATIVE stress CROSS-sectional method CASE-control method DATA analysis software DESCRIPTIVE statistics AUTOANALYZERS |
| Zdroj: | Dementia & Geriatric Cognitive Disorders; Dec2016, Vol. 42 Issue 5/6, p297-309, 13p, 2 Charts, 2 Graphs |
| Abstrakt: | Background/Aims: Oxidative stress is involved in Alzheimer disease pathology, but its impact on cognitive function in community-dwelling older adults remains unknown. We estimated associations between serum oxidative stress markers and cognitive function in early old age. Methods: Subjects aged 45-69 years recruited in urban centers in Central and Eastern Europe had memory, verbal fluency, and processing speed assessed at baseline (2002-2005) and 3 years later. Derivatives of reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP), and total thiol levels (TTLs) were measured at baseline in a subsample. Linear regression was used to estimate associations of biomarkers with cognitive test scores crosssectionally ( n = 4,304) and prospectively ( n = 2,882). Results: Increased d-ROM levels were inversely associated with global cognition and verbal fluency cross-sectionally and in prospective analysis; observed effects corresponded to 3-4 years' higher age. TTL was inconsistently associated with memory. BAP was not related to cognitive function. Conclusion: This study found modest evidence for a relationship between serum d-ROMs and cognitive function in a population sample of older adults. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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