Transcobalamin 776C→G polymorphism is associated with peripheral neuropathy in elderly individuals with high folate intake.
| Autor: | Sawaengsri, Hathairat, Bergethon, Peter R., Wei Qiao Qiu, Scott, Tammy M., Jacques, Paul F., Selhub, Jacob, Paul, Ligi |
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| Předmět: |
GERIATRIC nutrition
ALLELES ANALYSIS of covariance ANALYSIS of variance ANTHROPOMETRY CARRIER proteins CHI-squared test COMPARATIVE studies CONFIDENCE intervals DIET FOLIC acid GENETIC polymorphisms HEALTH status indicators LONGITUDINAL method NEUROPSYCHOLOGICAL tests PERIPHERAL neuropathy NEUROLOGIC examination NUTRITIONAL assessment PROBABILITY theory QUESTIONNAIRES RESEARCH funding STATISTICAL hypothesis testing STATISTICS VITAMIN B12 LOGISTIC regression analysis DATA analysis HOMEBOUND persons CROSS-sectional method DATA analysis software DESCRIPTIVE statistics ODDS ratio GENOTYPES |
| Zdroj: | American Journal of Clinical Nutrition; 12/1/2016, Vol. 104 Issue 6, p1665-1670, 6p |
| Abstrakt: | Background: The 776C→G polymorphism of the vitamin B-12 transport protein transcobalamin gene (TCN2) (rs1801198; Pro259Arg) is associated with a lower holotranscobalamin concentration in plasma. This effect may reduce the availability of vitamin B-12 to tissues even when vitamin B-12 intake is adequate. Clinical outcomes associated with vitamin B-12 insufficiency could potentially be worsened by high folate intake. Objective: We determined the association of the TCN2 776C→G polymorphism and folate intake with peripheral neuropathy in elders with normal plasma concentrations of vitamin B-12. Design: Participants in this cross-sectional study (n = 171) were from a cohort of community-based, home-bound elderly individuals aged ≥60 y who underwent an evaluation by physicians including an assessment for peripheral neuropathy. Participants were administered food-frequency and general health status questionnaires, anthropometric measurements were taken, and a fasting blood sample from each subject was collected. Results: Odds of neuropathy were 3-fold higher for GG genotypes than for CC genotypes (OR: 3.33; 95% CI: 1.15, 9.64). When folate intake was >2 times the Recommended Dietary Allowance (800 μg), GG genotypes had 6.9-fold higher odds of neuropathy than CC genotypes (OR: 6.9; 95% CI: 1.31, 36.36). There was no difference between the genotypes in the odds of peripheral neuropathy when folate intake was ≤800 μg (OR: 1.5; 95% CI: 0.18, 12.33). Conclusion: The TCN2 776C→G polymorphism is associated with increased odds of peripheral neuropathy in the elderly, even with a normal vitamin B-12 status, especially if their folate intake is >2 times the Recommended Dietary Allowance. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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