Reflections on HLA epitope-Based Matching for Transplantation.

Autor: Duquesnoy, Rene J.
Předmět:
Zdroj: Frontiers in Immunology; 11/28/2016, Vol. 7, p1-8, 8p
Abstrakt: HLA antibodies are primary causes of transplant rejection; they recognize epitopes that can be structurally defined by eplets. There are many reviews about HLA epitope-based matching in transplantation. This article describes some personal reflections about epitopes including a historical perspective of HLA typing at the antigen and allele levels, the repertoires of antibody-verified HLA epitopes, the use of HLAMatchmaker in determining the specificities of antibodies tested in different assays, and, finally, possible strategies to control HLA antibody responses. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index