| Autor: |
Shvetsov, A., Batotsyrenova, E., Stepanov, S., Ivanov, M. |
| Zdroj: |
Neurochemical Journal; Oct2016, Vol. 10 Issue 4, p308-311, 4p |
| Abstrakt: |
The markers of impairments of the nervous system were evaluated in rats at various time points after a sodium thiopental injection at the LD using biochemical and immunohistochemical methods. The thiopental coma state was associated with a decrease in the levels of superoxide dismutase 6 h after the injection, glucose-6-phosphate dehydrogenase 24 and 72 h after the injection, and pigment epithelium-derived factor 6᾿2 h after the injection, as well an increase in the levels of glutathione peroxidase 72 h after the injection and caspase-3 6 h after the injection in the blood plasma of rats. Immunohistochemical study of caspase-3 in the brain tissue revealed increased expression of the enzyme in the sensorimotor cortex and hippocampus 3 days after the thiopental injection. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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