| Autor: |
D'Alessandro#Gandolfo, Luciana, Ameglio, Franco, Biolcati, Gianfranco, Pimpinelli, Fulvia, Trento, Elisabetta, Galante, Marisa, Nardi, Armando, Topi, Giancarlo |
| Předmět: |
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| Zdroj: |
Journal of the European Academy of Dermatology & Venereology; May96, Vol. 6 Issue 3, p226-231, 6p |
| Abstrakt: |
Aim: Analysis of the prevalence of serum 1gM antibodies directed against the HCV-core antigen (HCV-lgM) in patients with Porphyria cutanea tarda (PCT), taking into account the hepatic histological picture, liver biochemical markers and the PT biochemical indices. Background: Hepatic damage, especially that due to HCV infection, has been previously reported as a PCT trigger. HCV-IgM reactivity, a marker of chronic HCV hepatitis. suggested to be related to active virus replication could also he related to the PCT clinical course. Methods: Blood samples of 97 patients, previously analyzed for a panel of clinical, histological and laboratory variables, followed in our Centre for Porphyria! stored at - 80°C, were available to be retrospectively assayed for anti-HCV-core 1gM (HCV-IgM, ELISA). Results: 61% HCV-IgM positivity was found, with no apparent significant relationship with the respective histological hepatitis classification, PCT remission phase, and PCT familiarity, when evaluated on overall patients. The levels of HCV-IgM presented a peculiar behaviour when correlated to the serum AST values. In fact, there was a significant positive correlation in those with HCV-IgM <4 and a not significant, inverse correlation in the remaining group. These two groups showed other differences: the HCV-IgM levels were correlated to histology, PCT remission and to the markers of liver disease (such as AST and ALT) only in the first group. Conclusion: a relationship between IgM response. PCT activity and the underlying liver disease is suggested. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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