| Autor: |
Hunter, D J, Riboli, E, Haiman, C A, Albanes, D, Altshuler, D, Chanock, S J, Haynes, R B, Henderson, B E, Kaaks, R, Stram, D O, Thomas, G, Thun, M J, Blanché, H, Buring, J E, Burtt, N P, Calle, E E, Cann, H, Canzian, F, Chen, Y C, Colditz, G A |
| Předmět: |
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| Zdroj: |
Nature Reviews Cancer; Dec2005, Vol. 5 Issue 12, p977-985, 9p |
| Abstrakt: |
Most cases of breast and prostate cancer are not associated with mutations in known high-penetrance genes, indicating the involvement of multiple low-penetrance risk alleles. Studies that have attempted to identify these genes have met with limited success. The National Cancer Institute Breast and Prostate Cancer Cohort Consortium--a pooled analysis of multiple large cohort studies with a total of more than 5,000 cases of breast cancer and 8,000 cases of prostate cancer--was therefore initiated. The goal of this consortium is to characterize variations in approximately 50 genes that mediate two pathways that are associated with these cancers--the steroid-hormone metabolism pathway and the insulin-like growth factor signalling pathway--and to associate these variations with cancer risk. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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