| Autor: |
Bezborodova, O., Nemtsova, E., Gevorkov, A., Boyko, A., Venediktova, J., Alekseenko, I., Kostina, M., Monastyrskaya, G., Sverdlov, E., Khmelevskiy, E., Yakubovskaya, R. |
| Předmět: |
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| Zdroj: |
Doklady Biochemistry & Biophysics; Sep2016, Vol. 470 Issue 1, p345-348, 4p |
| Abstrakt: |
Antitumor efficacy of the combined suicide gene therapy and radiotherapy was studied on the model of CT26 murine colon adenocarcinoma. CMV-FCU1-IRES-mGM-CSF-pGL3 construct with PEG-PEI-TAT (FCU1-mGM/5-FC) block copolymer as a vector was used for intratumoral administration. Tumors were irradiated with a single 5 Gy dose. The efficacy was evaluated according to the grade of tumor growth inhibition (T/C) and lifespan of the animals. Pronounced antitumor activity of the combined use of FCU1-mGM/5-FC system with radiotherapy on the background of prolonged lifespan and the synergism of the applied methods was revealed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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