| Autor: |
Jenkins, Rachel E., Shornick, Jeff K., Black, Martin M. |
| Předmět: |
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| Zdroj: |
Journal of the European Academy of Dermatology & Venereology; Aug93, Vol. 2 Issue 3, p163-173, 11p |
| Abstrakt: |
PG is a rare autoimmune bullous dermatosis of pregnancy that is characterised by linear deposition of C3, and occasionally IgG, along the BMZ of lesional, perilesional and clinically normal skin when examined by direct immunofluorescence. Frequently there is a circulating IgG[SUB1] autoantibody (PG factor) directed against a BMZ antigen that avidly binds complement. The aberrant expression of MHC class II molecules in the placenta is important in triggering the immune response against a glycoprotein of 180 kDa found in the lamina lucida of the basement membrane of the amnion which cross reacts with that in the skin. The deposition of immune reagents in the placentae in PG has been implicated in the placental dysfunction and impaired foctal outcome which has been shown to occur in PG. At present immunofluorescence is the key to differentiating PG from other clinically similar diseases. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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