Topical delivery of diclofenac into and across equine skin from a novel liquid diclofenac epolamine formulation.

Autor: Río‐Sancho, S., Concas, D., Oreste, P., Zoppetti, G., Briggs, P. H., Kalia, Y. N.
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Zdroj: Journal of Veterinary Pharmacology & Therapeutics; Dec2016, Vol. 39 Issue 6, p578-583, 6p
Abstrakt: The aim was to investigate diclofenac delivery into and across equine skin in vitro using Franz diffusion cells from a novel diclofenac epolamine ( DIC- EP; 1.3%) formulation and to compare the results to those of Surpass® (1% diclofenac sodium liposomal cream) and a 1% aqueous solution of diclofenac sodium. Skin was harvested from the lower legs of Freiberger geldings immediately after slaughter and sliced to a thickness of ~2 mm. Skin samples were divided into two groups [Group 1: 1 year old ( n = 2) and Group 2: 6-8 years old ( n = 3)]. Cumulative permeation of diclofenac in Groups 1 and 2 after 24 h using diclofenac sodium solution was 1.91 ± 0.27 and 1.76 ± 0.34 μg/cm2, respectively. The values for Surpass® and DIC- EP were 3.2 ± 0.8/3.3 ± 0.7 μg/cm2 and 230 ± 59/89.2 ± 32.5 μg/cm2, respectively. Thus, diclofenac permeation from DIC- EP was significantly greater and appeared to show an age-dependent effect. Mathematical modelling showed that the DIC- EP formulation significantly increased diclofenac partitioning into the skin and a linear correlation was observed between steady-state flux and the partition parameter. Greater skin deposition of diclofenac was also observed with DIC- EP. These preliminary results suggest that the DIC- EP formulation may be effective in treating inflammatory conditions in horses. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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