| Autor: |
Coman, Anca G., Paraschivescu, Codruta C., Hadade, Niculina D., Juncu, Andrei, Vlaicu, Ovidiu, Popescu, Costin-Ioan, Matache, Mihaela |
| Předmět: |
|
| Zdroj: |
Synthesis; 2016, Vol. 48 Issue 22, p3917-3923, 7p |
| Abstrakt: |
Peptidyl-acyloxymethyl ketones (AOMKs) belong to a class of selective, irreversible inhibitors (activity-based probes) widely used as chemical tools of investigating proteins, for example, in activity-based protein profiling. The synthesis of the AOMKs has always been challenging and current methodologies involve both solution and solid-phase synthesis. Herein, the synthesis of a new scaffold useful for the preparation of peptidyl-AOMKs is reported and it is demonstrated that the new synthetic probes bearing a 4-functionalized 2,6-dimethylbenzoate efficiently inhibit cysteine proteases like cathepsin B. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
