| Autor: |
Cavalcante-Silva, Luiz Henrique Agra, Correia, Ana Carolina de Carvalho, Sousa, Jéssica Celestino Ferreira, Barbosa-Filho, José Maria, Santos, Bárbara Viviana de Oliveira, de Miranda, George Emmanuel C., Alexandre-Moreira, Magna Suzana, Cavalcante, Fabiana de Andrade |
| Zdroj: |
Natural Product Research; Nov2016, Vol. 30 Issue 22, p2605-2610, 6p |
| Abstrakt: |
Previously, we demonstrated that caulerpine has spasmolytic effect on guinea pig ileum. The aim of this study was to investigate pathways of its spasmolytic action. We test caulerpine against phasic contractions induced by carbachol in the circular layer of guinea pig ileum and this alkaloid did not inhibit these contractions, indicating that caulerpine did not interfering with the mobilisation of Ca2+ from intracellular stores. Additionally, the spasmolytic effect of caulerpine did not involve K+ channels. Furthermore, we observed that α2-adrenergic receptors were not involved in the spasmolytic effect of caulerpine, since the relaxation curve induced by caulerpine was not shifted in the presence of yohimbine (α2-adrenergic antagonist). However, in the presence of propranolol (β-adrenergic antagonist), the relaxation curve induced by caulerpine was right-shifted, resulting in a fivefold increase in EC50. Thus, a possible mechanism for the spasmolytic action of caulerpine is the activation of β-adrenergic receptors. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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