| Abstrakt: |
Controlled drug delivery system is the one, which delivers the drug at a predominant rate, locally or systematically, for a specific period of time. The aim of work was performed to formulate and evaluate transdermal patches for sustained release of combined antiasthmatic drugs (Budesonide & Salmeterol Xinafoate) using HPMC K15 M, PVP K30, EC & other additives was prepared by solvent casting method. Ethanol was incorporated in the transdermal system because it significantly enhanced the permeation rate of budesonide & salmeterol xinafoate. The main objective of formulating the transdermal system was to prolong the drug release time, reduce the frequency of administration and to improve patient compliance. The prepared films evaluated satisfactory, physicochemical charaters such as thickness, drug content, percentage moisture content, percentage moisture uptake, water vapour permeability, weight uniformity, folding endurance. In vitro drug release was determined using rat abdominal skin membrane using franz diffusion cell. The patches were found to be thin and smooth & F3 showed maximum permeation of both drugs after 24 hrs (i.e. 89.75% of budesonide & 88.13% salmeterol xinafoate). The prepared transdermal drug delivery system of budesonide & salmeterol xinafoate using different polymers such as HPMC, EC had shown good promising results for all the evaluated parameters. Based on the In-vitro drug release and drug content Result, formulation F3 was considered as an optimized formulation, which shows its higher percentage of drug release. [ABSTRACT FROM AUTHOR] |
