| Autor: |
Thota, Sreekanth, Vallala, Srujana, Yerra, Rajeshwar, Rodrigues, Daniel, Barreiro, Eliezer |
| Zdroj: |
Medicinal Chemistry Research; Oct2016, Vol. 25 Issue 10, p2127-2132, 6p |
| Abstrakt: |
The synthesis and characterization of ruthenium complexes ( Ru-1-Ru-6) of the type [Ru(R)(K)] (where R = 1,10-phenanthroline/2,2′-bipyridyl and K = acetyl coumarin-inh, pyrazole-tch, acetyl coumarin-tsz, are described. These ligands form bidentate octahedral ruthenium complexes. The in vitro cytotoxic activities of the complexes measurement against the human cancer T-lymphocyte cell lines. In vitro evaluation of these title complexes revealed cytotoxicity from 0.34 to 1.4 µg/mL against CEM, 0.28 to 1.8 µg/mL against L1210, 0.44 to 2.5 µg/mL against Molt4/C, 0.98 to 1.6 µg/mL against HL60, and 0.66 to 1.4 µg/mL against BEL7402. Ruthenium complexes Ru-5 & Ru-6 showed that quite significant anticancer activities over standard drugs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink