| Autor: |
Naismith, S.L., Hickie, I.B., Little, C.L., Ward, P.B., Scott, E.M. |
| Předmět: |
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| Zdroj: |
Australian Journal of Psychology; Aug2003 Supplement, Vol. 55, p157-157, 1/4p |
| Abstrakt: |
Functional neuroimaging research has shown implicit sequence learning to recruit the basal ganglia, an area thought to underpin psychomotor change in depressive disorders. This study utilised an implicit learning 'probe' in association with functional magnetic resonance imaging (fMRI) to elucidate correlates of fronto-subcortical function in depression. Sixteen patients with DSM-IV major depression (mean age = 54.2, SD = 12.8, 10 female; mean years of education = 11.9 years, SD = 2.9) were tested using a 1.5-Tesla GE Sigma LX scanner. While in the scanner, subjects performed a four-choice reaction time task which comprised three blocks of implicit sequence learning (6 presentations of a fixed 12-item sequence) interspersed amongst 4 blocks of baseline (24 stimuli in pseudo-random locations). Implicit learning was defined as a significantly faster reaction time for the implicit learning blocks compared to baseline. Structural and functional data were co-registered and statistical parametric maps were created for each subject. Patients who 'Learned' (N = 10) demonstrated more diffuse patterns of activation than the 'Non-Learning' group (N = 6) and had significantly more activation in the left caudate nucleus (t = 2.2, p <. 01) and inferior frontal gyrus (t = 3.3, p <. 01). This study demonstrates the utility of fMRI to examine front-striatal circuits in depression whereby discrete brain regions are associated with implicit sequence learning. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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