Microwave-assisted neat synthesis of α-aminophosphonate/phosphinate derivatives of 2-(2-aminophenyl)benzothiazole as potent antimicrobial and antioxidant agents.

Autor: Thaslim Basha, Shaik, Sudhamani, Hasti, Rasheed, Syed, Venkateswarlu, Nagam, Vijaya, Tartte, Naga Raju, Chamarthi
Předmět:
Zdroj: Phosphorus, Sulfur & Silicon & the Related Elements; 2016, Vol. 191 Issue 10, p1339-1343, 5p
Abstrakt: A series of diethyl/ethylphenyl {2-(benzo[d]thiazol-2-yl)phenylamino}phosphonates and phosphinates were synthesized under microwave irradiation and neat conditions via Kabachnik-Fields reaction in high yields (80%–93%). The compounds were screened for antimicrobial and antioxidant properties. A few compounds showed effective antibacterial and antifungal activities at MIC value 12.5 μg/mL as compared with the standard at MIC value 6.25 μg/mL. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index