| Autor: |
Frazer, Ashlyn, Williams, Jacqueline, Spittles, Michael, Rantalainen, Timo, Kidgell, Dawson |
| Zdroj: |
Muscle & Nerve; Nov2016, Vol. 54 Issue 5, p903-913, 11p |
| Abstrakt: |
Introduction: We examined the cumulative effect of 4 consecutive bouts of noninvasive brain stimulation on corticospinal plasticity and motor performance, and whether these responses were influenced by the brain-derived neurotrophic factor (BDNF) polymorphism.Methods: In a randomized double-blinded cross-over design, changes in strength and indices of corticospinal plasticity were analyzed in 14 adults who were exposed to 4 consecutive sessions of anodal and sham transcranial direct current stimulation (tDCS). Participants also undertook a blood sample for BDNF genotyping (N = 13).Results: We observed a significant increase in isometric wrist flexor strength with transcranial magnetic stimulation revealing increased corticospinal excitability, decreased silent period duration, and increased cortical voluntary activation compared with sham tDCS.Conclusions: The results show that 4 consecutive sessions of anodal tDCS increased cortical voluntary activation manifested as an improvement in strength. Induction of corticospinal plasticity appears to be influenced by the BDNF polymorphism. Muscle Nerve 54: 903-913, 2016. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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