| Abstrakt: |
Superficial leiomyosarcomas are rare tumors. The lesions confined to the dermis, contrary to those involving the subcutis, have been reported to carry a favorable prognosis. A retrospective study of 41 consecutive cases of surgically treated intradermal and subcutaneous leiomyosarcomas was undertaken in order to determine the prognostic factors that may influence the survival of these patients. Seven tumors were predominantly intradermal and 34 involved the subcutaneous tissue. Fifty-four percent of the tumors were located in the lower extremities. All cases stained positively for smooth muscle antigen and 66% for desmin. The tumors were classified with regard to tumor grade I (low grade, 3%), II (intermediate, 12%), IIIA (high grade, 46%) and IIIB (high grade, 39%). In all patients, follow-up information was available. Mean follow-up time was 5 years. The patients with intradermal tumors were all alive without signs of recurrence, whereas 14 of those with leiomyosarcomas involving the subcutis have died with pulmonary metastases. Our study confirms that "pure" intradermal leiomyosarcomas independent of tumor grade behave in a benign fashion, probably due to small tumor size. Tumor size ≥ 5 cm, deep localization with fascia involvement, and high malignancy grade (IIIB) were found to deteriorate survival based on a univariate analysis. However, in a multivariate analysis only tumor size was found to be an independent prognostic factor. [ABSTRACT FROM AUTHOR] |
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