| Autor: |
Valentin, Antonio, Selway, Richard, Amarouche, Meriem, Mundil, Nilesh, Ughratdar, Ismail, Ayoubian, Leila, Martin-Lopez, David, Kazi, Farhana, Dar, Talib, Alarcon, Gonzalo |
| Zdroj: |
Stereotactic & Functional Neurosurgery; 2016 Supplement 1, Vol. 94, p80-81, 2p |
| Abstrakt: |
Objectives: A pilot study evaluating the efficacy of intracranial stimulation at treating medically refractory epielpsy in children. Methods: A retrospective analysis of eight children who underwent intracranial electrical stimulation for the investigation and treatment of their refractory epilepsy at King's College Hospital between 2014 and 2015. Five had subacute cortical stimulation (SCS) during intracranial video-telemetry with efficacy of stimulation evaluated by counting interictal discharges and seizures (both clinical and subclinical). Three other children underwent deep brain stimulaton (DBS) of the centromedian (two patients) or anterior (one patient) thalamic nuclei. The incidence of interictal discharges was evaluated visually and quantified automatically. Results: Three patients had thalamic DBS (one with idiopathic generalized epilepsy, one with presumed symptomatic generalized epilepsy and one with right fronto-temporal epilepsy) and 5 patients had SCS (one with temporal lobe epilepsy and four with frontal lobe epilepsy). Among the three children with DBS, two had >60% improvement in seizure frequency and severity and one had no improvement. Among the five children undergoing SCS, four showed improvement in seizure frequency (>50%), severity of seizures and interictal epileptiform discharges (>75%) while one chid did not show improvement. Procedures were well tolerated by all children. Conclusion: Cortical and thalamic stimulation appear to be effective and well tolerated in children with refractory epilepsy. Subacute cortical stimulation can be used to identify the focus and predict the effects of resective surgery. Further larger studies are necessary. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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