| Autor: |
Bewernick, Bettina H., Schlaepfer, Thomas Eduard, Braeuer, Alena, Bostroem, Jan, Urbach, Horst, Coenen, Volker Arnd |
| Zdroj: |
Stereotactic & Functional Neurosurgery; 2016 Supplement 1, Vol. 94, p49-49, 1/2p |
| Abstrakt: |
Background: Several targets for deep brain stimulation (DBS) have proven antidepressant efficacy for the treatment of otherwise treatment-resistant depression (TRD): a reduction of symptom severity of 50% in about 50% of patients could be demonstrated. The supero-lateral branch of the medial forebrain bundle (slMFB) was hypothesized to be a more efficacious target and rapid antidepressant effects were observed in seven patients. Longterm clinical data including quality of life, side effects and cognition covering four years are presented in order to evaluate clinical efficacy. Methods: Eight patients suffering from TRD were treated with DBS bilaterally to the slMFB. Primary outcome criterion was a 50% reduction in depression severity at 12 months compared to baseline. Secondary measures were general functioning, quality of life, safety and cognition as assessed for up to for 4 years. Results: Six of eight patients were responders at 12 months (75%), among them, four patients were remitters (50%). Longterm results revealed a stable antidepressant effect for up to four years. Clinical efficacy was also reflected in a substantial improvement of the global assessment of functioning. Main side effect was strabism at higher stimulation currents. No change in cognition was identified. Timeline analysis revealed a significant reduction in depression for 7/8 patients in all months (87.5%). Conclusions: Long-term results of DBS to the slMFB for TRD suggest a rapid and sustained antidepressant effect; timeline analysis may be a more meaningful approach in assessing longterm outcome in TRD clinical studies. In order to validate the antidepressant effect of slMFB-DBS, the inclusion of a sham phase in further studies is needed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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