False positives in breast cancer screening with one-view breast tomosynthesis: An analysis of findings leading to recall, work-up and biopsy rates in the Malmö Breast Tomosynthesis Screening Trial.

Autor:	Lång, Kristina, Nergården, Matilda, Andersson, Ingvar, Rosso, Aldana, Zackrisson, Sophia
Předmět:	BREAST cancer diagnosis TOMOSYNTHESIS MAMMOGRAMS FIBROADENOMAS CYSTS (Pathology) BIOPSY BREAST BREAST tumors CLINICAL trials COMPARATIVE studies DIAGNOSTIC errors LONGITUDINAL method RESEARCH methodology MEDICAL cooperation RESEARCH EVALUATION research CONNECTIVE tissue tumors EARLY detection of cancer
Zdroj:	European Radiology; Nov2016, Vol. 26 Issue 11, p3899-3907, 9p
Abstrakt:	Objectives: To analyse false positives (FPs) in breast cancer screening with tomosynthesis (BT) vs. mammography (DM).Methods: The Malmö Breast Tomosynthesis Screening Trial (MBTST) is a prospective population-based study comparing one-view BT to DM in screening. This study is based on the first half of the MBTST population (n = 7,500). Differences in FP recall rate, findings leading to recall, work-up and biopsy rate between cases recalled on BT alone, DM alone and BT+DM were analysed.Results: The FP recall rate was 1.7 % for BT alone (n = 131), 0.9 % for DM alone (n = 69) and 1.1 % for BT + DM (n = 81). The FP recall rate for BT alone was halved after the initial phase of the trial, stabilising at 1.5 %. BT doubled the recall of stellate distortions compared to DM (n = 64 vs. n = 33). There were fewer fibroadenomas and cysts, and the biopsy rate was slightly lower for FP recalled on BT alone compared to DM alone (15.3 % vs. 27.6 %: p = 0.037 and 33.8 % vs. 36.2 %; p = 0.641, respectively).Conclusions: FPs increased with BT screening mainly due to the recall of stellate distortions. The FP recall rate was still well within the European guidelines and showed evidence of a learning curve. Characterisation of rounded lesions was improved with BT.Key Points: • Tomosynthesis screening gave a higher false-positive recall rate than mammography • There was a decline in the false-positive recall rate for tomosynthesis • The recall due to stellate distortions simulating malignancy was doubled with tomosynthesis • Tomosynthesis found more radial and postoperative scar tissue than mammography • Tomosynthesis is better at characterising rounded lesions. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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