HIV Pharmacist's Impact on Inpatient Antiretroviral Errors.
| Autor: | Liedtke, MD, Tomlin, CR, Skrepnek, GH, Farmer, KC, Johnson, PN, Rathbun, RC |
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| Předmět: |
HIV infections
THERAPEUTICS HOSPITAL admission & discharge PATIENTS CHEMICAL laboratory equipment CHI-squared test CONTINUUM of care DRUG side effects HIV-positive persons HOSPITAL patients MULTIVARIATE analysis PHARMACISTS POISSON distribution STATISTICS HIGHLY active antiretroviral therapy ACQUISITION of data RETROSPECTIVE studies PATIENT selection TREATMENT duration TERTIARY care |
| Zdroj: | HIV Medicine; Nov2016, Vol. 17 Issue 10, p717-723, 7p |
| Abstrakt: | Objectives Transitions in care between out-patient and in-patient settings provide ample opportunity for medication errors to occur in HIV-infected patients. The purpose of this study was to examine the effectiveness of an HIV pharmacist monitoring service in decreasing antiretroviral medication errors in a large south central teaching hospital in the USA. Methods A retrospective, observational study was conducted to examine the frequency of antiretroviral medication errors in HIV-seropositive patients with hospital admissions between 1 September 2011 and 30 September 2013 at a single tertiary care centre in Oklahoma. Patient assignment to the 12-month pre-intervention and intervention study periods was determined by admission date. Demographic, laboratory, and in-patient medication data were collected. Bivariate analyses were conducted using χ2 analysis with the Yates correction factor for continuity to examine frequencies in specific antiretroviral classes and error categories. A multivariable Poisson regression was employed to examine the frequency of medication errors before and after initiation of the pharmacist service. Results Medication errors were examined in a total of 330 patient admissions during the 2-year study period. A multivariable-adjusted decrease of 73.9% in the number of errors was observed between the pre-intervention and intervention periods ( P < 0.001). Patients on protease inhibitor regimens or with impaired renal function had 2.6-fold and 2.8-fold higher numbers of errors, respectively ( P < 0.001). Conclusions HIV pharmacist monitoring can decrease medication errors in HIV-infected patients as they transition between out-patient and in-patient care. Patients receiving protease inhibitor-based therapy or with renal insufficiency are at higher risk for medication errors upon admission. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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