| Autor: |
Piacenti ‐ Silva, Marina, Matos, Adriana Arruda, Paulin, João Vitor, Alavarce, Rafaela Alves da Silva, de Oliveira, Rodrigo Cardoso, Graeff, Carlos FO |
| Předmět: |
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| Zdroj: |
Polymer International; Nov2016, Vol. 65 Issue 11, p1347-1354, 8p |
| Abstrakt: |
Biocompatibility tests were performed for melanin synthesized in water (W-Mel) and dimethylsulfoxide (D-Mel) aiming to evaluate its potential for bioelectronics application. In vitro biocompatibility of melanin was assessed using crystal violet assays with fibroblast cells ( NIH3T3) cultured with W-Mel and D-Mel extracts in various dilutions. The results show that a high concentration of melanin kills the cells. However, after periods of 48 h incubation, cell viability is significantly favored after treatment with D-Mel at low concentrations (1:16, 1:32 and 1:64), as opposed to treatment with W-Mel extracts. Cellular adhesion tests show that fibroblast cells adhere to melanin thin films. These results show that D-Mel may be an interesting material for application in bioelectronic devices targeted for implants. © 2016 Society of Chemical Industry [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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