| Autor: |
Haftek, H., Euvard, S., Kanitakisd, J., Delawari, E., Schmitt, D. |
| Předmět: |
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| Zdroj: |
Journal of Cutaneous Pathology; Aug93, Vol. 20 Issue 4, p350-355, 6p |
| Abstrakt: |
An ultrastructural study of a typical case of acquired performing clermatosis in a patient with rnal failure and diabetes mellitus is reported. Crystal like microdeposits of an elcctron-Iucid material were detected in the upper dermis, close to the transepidermal channel. Compact macrophage conglomerations surrounded the deposits, and a strong histiocytic response was present. Mononuclear inflammatory cells of "activated" type penetrated acanthotic epidermis provoking basement membrane dissolution and widening of interkeratinocyte spaces. Collagen fibers were seen in the keratotic plug, indicating the process of transepidermal elimination. Our observation supports the hypothesis suggesting that some kind of storage phenomenon may be at the origin of perforating skin lesions in renal failure patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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