| Autor: |
Kanitakis, J., Zambruno, G., Viac, J., Tommaselli, L., Thivolet, J. |
| Předmět: |
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| Zdroj: |
Journal of Cutaneous Pathology; Oct89, Vol. 16 Issue 5, p272-276, 5p |
| Abstrakt: |
p29 is a cytoplasmic serine phosphoprotein of 29 kD MW, closely linked to estrogen receptors. In this work we studied the expression of p29 protein in normal human skin and a group of cutaneous benign and malignant tumors by using a monoclonal antibody (ERD5) that specifically recognizes p29. In normal skin, p29 reactivity was observed in epidermal and some ad- nexal keratinocytes, as well as in smooth muscle cells of dermal arterioles and arrector pili muscles. p29 was also detected in most, but not all, epithelial tumors studied. The expression of p29 was generally stronger in the more differentiated (kerati- nized) normal and neoplastic keratinocytes; however, no correla- tion could be noted between immunochemical staining for p29 and either benignity of the lesion or sex of the patient consid- ered. Whereas, in breast cancer, the expression of p29 is re- ported to correlate with endocrine response, the precise relation- ship between epithelial tumors of the skin and the action of estrogens remains to be elucidated. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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