| Autor: |
Stravalaci, Matteo, Beeg, Marten, Rossi, Alessandro, Salmona, Mario, Diomede, Luisa, Gobbi, Marco, Tapella, Laura, Balducci, Claudia, Forloni, Gianluigi, Chiesa, Roberto, Biasini, Emiliano, Joshi, Pooja, Pizzi, Erika, Mazzanti, Michele |
| Předmět: |
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| Zdroj: |
Journal of Alzheimer's Disease; 2016, Vol. 54 Issue 3, p1485-1497, 13p, 8 Graphs |
| Abstrakt: |
15B3 is a monoclonal IgM antibody that selectively detects pathological aggregates of the prion protein (PrP). We report the unexpected finding that 15B3 also recognizes oligomeric but not monomeric forms of amyloid-β (Aβ)42, an aggregating peptide implicated in the pathogenesis of Alzheimer’s disease (AD). The 15B3 antibody: i) inhibits the binding of synthetic Aβ42 oligomers to recombinant PrP and neuronal membranes; ii) prevents oligomer-induced membrane depolarization; iii) antagonizes the inhibitory effects of oligomers on the physiological pharyngeal contractions of the nematode Caenorhabditis elegans; and iv) counteracts the memory deficits induced by intracerebroventricular injection of Aβ42 oligomers in mice. Thus this antibody binds to pathologically relevant forms of Aβ, and offers a potential research, diagnostic, and therapeutic tool for AD. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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