| Autor: |
Cook, Ian A., Morgan, Melinda L., Dunkin, Jennifer J., David, Steven, Witte, Elise, Lufkin, Robert, Abrams, Michelle, Rosenberg, Susan, Leuchter, Andrew F. |
| Předmět: |
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| Zdroj: |
International Journal of Geriatric Psychiatry; Jul2002, Vol. 17 Issue 7, p610-618, 9p, 1 Color Photograph, 2 Charts, 1 Graph |
| Abstrakt: |
Background Cortical atrophy, central atrophy, deep white-matter hyperintensities, and periventricular hyperintensities are reported in normal aging. Objectives We examined the effects of estrogen replacement therapy (ERT) on these forms of ‘subclinical structural brain disease’ (SSBD) in normal, postmenopausal women in a pilot, naturalistic, longitudinal study of 15 subjects. Methods Two assessments were performed at least two years apart, with volumetric magnetic resonance imaging (MRI) and neuropsychological testing. Results Women receiving open-label ERT showed significantly less progression of SSBD than those who did not. Conclusions The association between reduced SSBD progression and ERT suggests this intervention could help preserve normal brain structure in healthy elderly women. Copyright © 2002 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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