| Autor: |
Georgouli, Helen, Getsi, Vasiliki, Psychou, Fotini, Tsapra, Helen, Zeis, Petros M., Gourgiotis, Dimitris, Matsinos, Yiannis G., Nicolaidou, Polyxeni |
| Předmět: |
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| Zdroj: |
Pediatric Nephrology; Nov2003, Vol. 18 Issue 11, p1157-1160, 4p, 2 Diagrams, 1 Chart |
| Abstrakt: |
Abstract Urinary excretion of endothelin-1 (ET-1) and plasma ET-1 were measured in 21 children with absorptive idiopathic hypercalciuria (AIH) and 22 controls. The absorptive type of idiopathic hypercalciuria was determined by a calcium loading test. Daily urinary excretion of ET-1 and urinary ET-1/creatinine ratio were significantly increased (P=0.005 and P=0.007, respectively) in patients with AIH (9,274±6,444 pg/24 h and 14.04±9.52 pg/mg, respectively) compared with controls (4,699±2,120 pg/24 h and 7.36±4.71 pg/mg, respectively). Plasma ET-1 levels were significantly lower in patients with AIH (0.84±0.64 pg/ml) than in controls (1.54±0.54 pg/ml, P=0.0001). In conclusion, patients with AIH had increased urinary ET-1 excretion and decreased plasma ET-1 levels. This is most likely due to the decreased reabsorption of ET-1 in the renal tubule and increased renal production. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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