Enhancing the bioavailability of mebendazole by integrating the principles solid dispersion and nanocrystal techniques, for safe and effective management of human echinococcosis.

Autor:	Chaudhary, Sushant, Garg, Tarun, Rath, Goutam, Murthy, Rs Rayasa, Goyal, Amit K.
Předmět:	DRUG solubility BIOAVAILABILITY MEBENDAZOLE ECHINOCOCCOSIS POLYETHYLENE glycol DISPERSION (Chemistry) CRYSTALLINE polymers NANOCRYSTALS
Zdroj:	Artificial Cells, Nanomedicine & Biotechnology; May2016, Vol. 44 Issue 3, p937-942, 6p
Abstrakt:	The method based on integrating the principles of solid dispersion and nanocrystal techniques was developed to prepare polymer crystals (PCs) of mebendazole (MBZ) and polyethylene glycol (PEG). Powder X-Ray diffraction (PXRD) of the PC crystals shows the required integrated crystalline and amorphous regions. Thein vitrosolubility studies showed a 32-fold increase in the solubility of the drug. Tests of dissolution of the PCs showed that the crystals have an enhanced dissolution rate in comparison to those in the MF. The results of the pharmacokinetic study showed a 2.12-fold increase in the bioavailability of the drug. Thus, the present study has proved the potential in enhancing solubility, dissolution, and bioavailability of the drug. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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