| Autor: |
Klein-Szanto, A. J. P., De Rey, B. M., Cabrini, R. L. |
| Předmět: |
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| Zdroj: |
Journal of Cutaneous Pathology; 1977, Vol. 4 Issue 1, p23-31, 9p |
| Abstrakt: |
The number of epithelial cells per unit volume of tissue (N[subv]) and the relative volume (V[subv]) occupied by the spinous and basal layers of X-irradiated and non-irradiated rat-tail epidermis were studied using techniques of stereologic cytology. By a simple calculation, the absolute volumes of basal and spinous keratinocytes were determined in irradiated (and in non-irradiated, control) epidermis, 24, 48, 72 and 96 11 after exposure to a single dose of 16 Krads. During this post-irradiation period, the absolute volumetric values of both basal and spinous keratinocytes increased gradually, reaching a three-fold increase 96 h after irradiation. At the same time, the relative volume of the spinous layer increased from 58% to 75% of the total epidermis, whereas the volume fraction occupied by the basal layer decreased from 20% to 16%. These findings support previous evidence that lethally and sublethally damaged keratinocy tes are capable of a metabolic effort resulting in a cell hypertrophy which in sonic circumstances could lead to repair and recovery from radiation damage. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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