| Autor: |
Szeszko, Philip R., Goldberg, Ethan, Gunduz-Bruce, Handan, Ashtari, Manzar, Robinson, Delbert, Malhotra, Anil K., Lencz, Todd, Bates, John, Crandall, David T., Kane, John M., Bilder, Robert M. |
| Předmět: |
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| Zdroj: |
American Journal of Psychiatry; Dec2003, Vol. 160 Issue 12, p2190-2197, 8p |
| Abstrakt: |
Objective: The authors investigated volumetric alterations of the anterior hippocampal formation in patients experiencing a first episode of schizophrenia relative to healthy comparison subjects. Method: From contiguous 1.5-mm coronal magnetic resonance images, the hippocampal formation was divided into posterior and anterior segments, and the anterior hippocampal formation was separated from the amygdala. Volumes of the posterior and anterior hippocarnpal formation and amygdala were computed in 46 (31 male and 15 female) patients experiencing a first episode of schizophrenia and in 34 (21 male and 13 female) healthy comparison subjects. Twenty-four patients were antipsychotic native at the time of the scan. Results: Patients had significantly reduced total (right plus left) anterior hippocampal formation volume relative to healthy comparison subjects but did not differ in volumes of either the posterior hippocampal formation or amygdala. Similar findings were obtained when analyses were restricted to the antipsychotic-naive subgroup of patients. Conclusions: These findings suggest that volumetric abnormalities of the hippocampus-amygdala complex may be specific to the anterior hippocampal formation in patients experiencing a first episode of schizophrenia and are consistent with hypotheses regarding abnormal frontolimbic connectivity playing a role in the pathophysiology of the disorder. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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