Palladium-Catalyzed Regioselective Direct Cyanation of Acetanilide Derivatives with K4[Fe(CN)6] by C-H Bond Activation.

Autor:	Kianmehr, Ebrahim, Faghih, Nasser, Tanbakouchian, Arezoo, Mahdavi, Mohammad
Předmět:	PALLADIUM catalysts ACETANILIDE CARBON-hydrogen bonds REGIOSELECTIVITY (Chemistry) DRUGS
Zdroj:	European Journal of Organic Chemistry; Sep2016, Vol. 2016 Issue 25, p4269-4274, 6p
Abstrakt:	A practical, versatile, and efficient method for the palladium-catalyzed direct cyanation of readily available acetanilides with K4[Fe(CN)6] as a safe cyanating agent through C-H bond activation with excellent C2 regioselectivity was developed. This finding represents a new strategy for the synthesis of N-(2-cyanoaryl)acetamides, which are important structural motifs in natural products and pharmaceuticals. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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