| Autor: |
Döffinger, Rainer, Helbert, Matthew R., Barcenas-Morales, Gabriela, Kun Yang, Dupuis, Stephanie, Ceron-Gutierrez, Lourdes, Espitia-Pinzon, Clara, Barnes, Neil, Bothamley, Graham, Casanova, Jean-Laurent, Longhurst, Hilary J., Kumararatne, Dinakantha S. |
| Předmět: |
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| Zdroj: |
Clinical Infectious Diseases; 1/1/2004, Vol. 38 Issue 1, pe10-e14, 5p |
| Abstrakt: |
We evaluated a patient with disseminated Mycobacterium tuberculosis and Mycobacterium chelonae infection, of which he died. He also developed autoimmune (type I) diabetes and primary hypothyroidism. His serum contained a high titer of immunoglobulin G autoantibody to interferon-γ (IFN-γ) capable of blocking in vitro responses to this cytokine by peripheral blood mononuclear cells from normal donors. These results suggest that autoantibodies to IFN-γ can induce susceptibility to disseminated mycobacterial infection, which may be refractory to chemotherapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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