| Autor: |
Cieśla, Andrzej, Krupiarz, Iwona Sobczyk, Skwara, Paweɫ, Jasik, Monika Bociąga, Owczarek, Danuta, Cibor, Dorota, Mach, Tomasz |
| Předmět: |
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| Zdroj: |
Experimental & Clinical Hepatology; 2012, Vol. 8 Issue 3/4, p8-12, 5p |
| Abstrakt: |
Background: Hepatitis C virus (HCV) infection in patients with advanced malignancies treated with cytostatics differs from HCV infection in general population due to additional factors connected with liver disease, like immunosuppression and drug-induced hepatotoxicity. Aim: To describe the effect of nosocomial HCV infection on the clinical course of hepatitis, efficiency of antiviral treatment and outcome in patients with advanced cancer. Material/Methods: A cohort of 24 women (mean age 47 years) with ovarian or breast cancers and acute HCV infection was studied. The control group consisted of 10 non-neoplastic patients infected with HCV during hospitalization at the same gynecology department. The diagnosis of acute hepatitis C (AHC) was based on both anti-HCV by EIA 3.0, HCV-RNA positive tests and elevated alanine aminotransferase (ALT). We studied: clinical symptoms, liver changes on ultrasonography, serum activity of ALT, g-glutamyltransferase (GGT), alkaline phosphatase and bilirubin level. Sixteen patients were treated with interferon a (IFN). Efficacy and tolerability of the therapy were assessed in both groups. Results: Spontaneous clearance of HCV was observed in 8% of patients with advanced malignancies. Sustained virological response was achieved in 51.7% of patients with cancer treated with pegylated IFN and ribavirin in the early phase of chronic hepatitis C. No severe liver damage was observed in patients with AHC treated with chemotherapy. No differences were found with respect to the clinical course of AHC between women with advanced cancer and control groups. Significantly lower ALT (p=0.02) and higher GGT (p=0.006) activities were observed in patients with advanced malignancies treated with cytostatic drugs in comparison to controls. Conclusions: Advanced malignancies and chemotherapy do not exclude the possibility of spontaneous HCV clearance and favourable virological response of majority of patients treated with IFN. Chemotherapy of patients with advanced cancer in the course of AHC was not a life-threatening condition. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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