| Autor: |
Chen Lin, Zaizhong Zhang, Yun Xu, Ruohan Wang, Shaoquan Chen, Jian Gao, Daiyong Wang, Qiaojia Huang, Xiaohuang Tu, Lie Wang |
| Předmět: |
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| Zdroj: |
American Journal of Clinical Pathology; Sep2016, Vol. 146 Issue 3, p278-288, 11p, 1 Color Photograph, 7 Charts, 1 Graph |
| Abstrakt: |
Objectives: To investigate the clinical and prognostic significance of high vascular endothelial growth factor (VEGF) expression in resected T3 gastric adenocarcinoma (GA). Methods: Data of VEGF expression on 453 patients with resected T3 GA were collected from a single institute in Fuzhou, China. VEGF expression in the resected tumor tissues was evaluated by immunohistochemistry (IHC). Associations between VEGF expression outcomes and prognosis were investigated using by the X² test, Kaplan-Meier plus log-rank test, and univariate and multivariate Cox models. Results: In total, 48.6% (220/453) patients had low VEGF expression (IHC score≤2+). Patients with high VEGF expression (IHC>2þ; 233/453, 51.4%) had significantly poorer median recurrence-free survival time (20 vs 55 months, P<.001) and median overall survival time (28 vs 58 months; P<.001) than patients with low VEGF. High VEGF was associated with higher overall recurrence (68.2% vs 51.4%, P=2.675×10-4), poorer overall survival (27.5% vs 47.3%, P=1.719×10-5), and increased risk of recurrence (hazard ratio [HR], 1.71; 95% confidence interval [CI], 1.33-2.19; P=2.43×10-5) and death (HR, 1.80; 95% CI, 1.41-2.3; P=2.19×10-6). Conclusions: High VEGF expression is associated with a higher risk of recurrence and shorter survival in resected T3 GA. These findings may provide a foundation for evaluating VEGF-targeted molecular therapies in T3 GA. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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