BRAFV600E mutation in a case of hairy cell leukaemia.

Autor: Sadiq, Muhammad Arif, Ahmed, Suhaib, Bhatti, Farhat Abbas, Ali, Nadir, Shamshad, Ghassan Umair
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Zdroj: Pakistan Journal of Pathology; Dec2011, Vol. 22 Issue 4, p156-159, 4p
Abstrakt: Hairy cell leukaemia is a clonal B cell lymphoproliferative disorder. Patient usually presents to clinician with cytopenias and splenomegaly. Common symptoms include abdominal discomfort, fatigue, generalized weakness, recurrent infections, bruising and bleeding complaints. We present a case of Hairy cell leukaemia with only 25% neoplastic cells in which BRAFV600E mutation was detected. Cytochemical stain, trephine biopsy and immunophenotyping were also consistent with Hairy cell leukaemia. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index