Functional polymorphisms in antioxidant genes in Hurthle cell thyroid neoplasm - an association of GPX1 polymorphism and recurrent Hurthle cell thyroid carcinoma.
| Autor: | Krhin, Blaz, Goricar, Katja, Gazic, Barbara, Dolzan, Vita, Besic, Nikola |
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| Předmět: |
REACTIVE oxygen species
ALLELES ANTIOXIDANTS CANCER relapse COMPARATIVE studies GENETIC polymorphisms GENETIC techniques GLUTATHIONE HISTOLOGICAL techniques METASTASIS OXIDOREDUCTASES PROBABILITY theory SUPEROXIDE dismutase LOGISTIC regression analysis OXIDATIVE stress THYROID gland tumors RETROSPECTIVE studies STATISTICAL models DESCRIPTIVE statistics GENOTYPES DIAGNOSIS TUMOR risk factors |
| Zdroj: | Radiology & Oncology; Sep2016, Vol. 50 Issue 3, p289-296, 8p |
| Abstrakt: | The article presents a study which investigations the association of common functional polymorphisms in antioxidant genes (SOD2, CAT, GPX, GSTP1, GSTM1 and GSTT1) with the development or clinical course of Hurthle cell thyroid carcinoma (HCTC). Materials and methods used in the study which involved 139 patients treated by thyroid surgery for a Hurthle cell neoplasm are offered. Results suggest the influence of GPX1 polymorphism on the risk for recurrent disease in HCTC. |
| Databáze: | Complementary Index |
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