| Autor: |
Lv, Zhi‐Dong, Yang, Zhao‐Chuan, Liu, Xiang‐Ping, Jin, Li‐Ying, Dong, Qian, Qu, Hui‐Li, Li, Fu‐Nian, Kong, Bin, Sun, Jiao, Zhao, Jiao‐Jiao, Wang, Hai‐Bo |
| Předmět: |
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| Zdroj: |
Journal of Cellular & Molecular Medicine; Sep2016, Vol. 20 Issue 9, p1640-1650, 11p |
| Abstrakt: |
Triple-negative breast cancer ( TNBC) is a highly aggressive tumour subtype associated with poor prognosis. The mechanisms involved in TNBC progression remains largely unknown. To date, there are no effective therapeutic targets for this tumour subtype. Paired-related homeobox 1b (Prrx1b), one of major isoforms of Prrx1, has been identified as a new epithelial-mesenchymal transition ( EMT) inducer. However, the function of Prrx1b in TNBC has not been elucidated. In this study, we found that Prrx1b was significantly up-regulated in TNBC and associated with tumour size and vascular invasion of breast cancer. Silencing of Prrx1b suppressed the proliferation, migration and invasion of basal-like cancer cells. Moreover, silencing of Prrx1b prevented Wnt/β-catenin signaling pathway and induced the mesenchymal-epithelial transition ( MET). Taken together, our data indicated that Prrx1b may be an important regulator of EMT in TNBC cells and a new therapeutic target for interventions against TNBC invasion and metastasis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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