| Autor: |
MANABU KANEKO, SHIN SASAKI, KOSUKE OZAKI, KAZUHIRO ISHIMARU, EMI TERAI, HIROSHI NAKAYAMA, TOSHIYUKI WATANABE |
| Předmět: |
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| Zdroj: |
Molecular & Clinical Oncology; 2016, Vol. 5 Issue 3, p289-294, 6p, 3 Charts, 1 Graph |
| Abstrakt: |
The aim of the present study was to evaluate the effect of underweight status on the survival of elderly patients undergoing surgery for colorectal cancer (CRC). A total of 113 patients aged ≥75 years who underwent curative surgery for CRC were included. In addition to standard perioperative variables, body mass index (BMI) was assessed. The patients were categorized as underweight (BMI<18.5 kg/m2) or non‑underweight (BMI≥18.5 kg/m2). The 3‑year overall survival (OS) and cancer‑specific survival (CSS) were analyzed. Of the 113 patients, 24 (21%) were underweight. The two groups were well‑balanced regarding all factors evaluated. In the multivariate analysis, underweight status was an independent indicator of lower 3‑year OS [hazard ratio (HR)=2.65; 95% confidence interval (CI): 1.08‑6.50; P=0.033] and CSS (HR=3.51, 95% CI: 1.16‑10.60; P=0.025) rates. Compared with the non‑underweight group, the underweight group had significantly worse 3‑year OS (66.7 vs. 86.5%, respectively; P=0.017) and CSS (74.1 vs. 90.9%, respectively; P=0.025) rates. Therefore, underweight status was a significant risk factor for poor survival in elderly CRC patients. The development of effective nutritional interventions may improve the prognosis of such patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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