Sustained virological response after a 17-day treatment with daclatasvir plus asunaprevir in a cirrhotic patient with hepatitis C virus genotype 1b and null response for peginterferon ribavirin therapy.

Autor: Sato, Akira, Ishii, Toshiya, Adachi, Kayo, Kumon, Daisuke, Tamura, Tomohiro, Noguchi, Youhei, Matsumoto, Nobuyuki, Okuse, Chiaki
Zdroj: Clinical Journal of Gastroenterology; Apr2016, Vol. 9 Issue 2, p89-92, 4p
Abstrakt: Daclatasvir (DCV) plus asunaprevir (ASV) treatment, an oral therapy for chronic hepatitis C virus (HCV) genotype 1b infection, can achieve a high sustained viral response (SVR) rate within a 24-week treatment period. A 55-year-old Japanese female with cirrhosis and null response for peginterferon plus ribavirin therapy received DCV plus ASV therapy, but she reported a slight fever beginning on treatment day 4. The fever increased to >38.0 °C beginning on treatment day 15 and could not be controlled with antipyretics; thus, the treatment was discontinued on day 17. Although the patient was still positive for HCV RNA 6 days after treatment discontinuation, she achieved an SVR at week 24 after treatment cessation. In some patients with HCV genotype 1b infection, an SVR can be achieved with short-term DCV plus ASV treatment, and HCV RNA positivity at the end of treatment does not always indicate virological failure. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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